Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 51, Issue -, Pages 90-106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2015.09.001
Keywords
Animal models; Calcium channels; Diabetes; Retinitis pigmentosa; MRI; Retinopathy; Subretinal space; Vision
Categories
Funding
- Juvenile Diabetes Research Foundation
- Mouse Metabolic and Phenotyping Centers Pilot and Feasibility Program
- National Eye Institute
- Beckman Foundation
- Wayne State University Bridge Funding
- Research to Blindness
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Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases. (C) 2015 Published by Elsevier Ltd.
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