Journal
PROGRESS IN LIPID RESEARCH
Volume 61, Issue -, Pages 149-162Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2015.11.002
Keywords
PPAR gamma; Adipogenesis; Polyunsaturated fatty acids; Cyclooxygenases; Lipoxygenases; Reactive oxygen species
Funding
- Danish Natural Science Research Council [0602-00605B]
- Villum Foundation
- Novo Nordisk Foundation
- Lundbeck Foundation
- Carlsberg Foundation [2012_01_0584]
- EU FP7 project DIABAT [HEALTH-F2-2011-278373]
- United States Department of Agriculture intramural project [2032-51530-022-00D]
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The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is the key decisive factor controlling the development of adipocytes. Ligand-mediated activation of PPAR gamma occurs early during adipogenesis and is thought to prime adipose conversion. Although several fatty acids and their derivatives are known to bind to and activate PPAR gamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation is still a matter of debate. Here we review recent data on pathways involved in ligand production as well as possible endogenous, adipogenic PPAR gamma agonists. (C) 2015 Elsevier Ltd. All rights reserved.
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