Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 120, Issue 1-3, Pages 28-36Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2016.01.001
Keywords
Popeye domain containing genes; cAMP; Protein-protein interaction; Ion channel; Cardiac arrhythmia; Animal models
Categories
Funding
- Medical Research Council [MR/J010383/1]
- British Heart Foundation [PG/14/46/30911, PG/14/83/31128]
- Magdi Yacoub Institute [HSC324/14, HSC326/14]
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Popeye domain containing (Popdc) proteins are a unique family, which combine several different properties and functions in a surprisingly complex fashion. They are expressed in multiple tissues and cell types, present in several subcellular compartments, interact with different classes of proteins, and are associated with a variety of physiological and pathophysiological processes. Moreover, Popdc proteins bind the second messenger cAMP with high affinity and it is thought that they act as a novel class of CAMP effector proteins. Here, we will review the most important findings about the Popdc family, which accumulated since its discovery about 15 years ago. We will be focussing on Popdc protein interaction and function in striated muscle tissue. However, as a full picture only emerges if all aspects are taken into account, we will also describe what is currently known about the role of Popdc proteins in epithelial cells and in various types of cancer, and discuss these findings with regard to their relevance for cardiac and skeletal muscle. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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