Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 34, Pages 9440-9445Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1604231113
Keywords
organic electronics; controlled delivery; electrophysiology; epilepsy; therapy
Categories
Funding
- European Union's Seventh Framework Programme (EPITARGET) [602102]
- Initiative of Excellence Aix-Marseilles project MIDOE [A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS]
- Swedish Innovation Office [2010-00507]
- Swedish Research Council [621-2011-3517]
- Knut and Alice Wallenberg Foundation (KAW Scholar) [2012.0302]
- National Science Foundation [DMR-1105253]
- French National Research Agency (ANR) through the project PolyProbe [ANR-13-BSV5-0019-01]
- Fondation pour la Recherche Medicale [DBS20131128446, ARF20150934124]
- Fondation de l'Avenir
- Onnesjo Foundation
- Region Provence-Alpes-Cote d'Azur
- Microvitae Technologies
- Marie Curie Fellowships
- Vinnova [2010-00507] Funding Source: Vinnova
Ask authors/readers for more resources
Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional neural pixel creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available