Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 23, Pages 6338-6344Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1606335113
Keywords
Salmonella Typhi; typhoid fever; bacterial pathogenesis; bacterial toxins; cell autonomous immunity
Categories
Funding
- National Institute of Allergy and Infectious Diseases [AI055472, AI079022]
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Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans throughout history and continues to be a major public health concern. Unlike infections with most other Salmonellae, which result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease. Furthermore, in contrast to most Salmonellae, which can infect a broad range of hosts, S. Typhi is a strict human pathogen. The unique features of S. Typhi pathogenesis and its stringent host specificity have been a long-standing puzzle. The discovery of typhoid toxin not only has provided major insight into these questions but also has offered unique opportunities to develop novel therapeutic and prevention strategies to combat typhoid fever.
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