Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 50, Pages E8141-E8150Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1617460113
Keywords
microbiota; Th17 cells; probiotic; mucosal immunology; intestine
Categories
Funding
- UCB (Union Chimique Belge)
- NIH [R01AI107117]
- Agency for Science, Technology, and Research Graduate Scholarship Fellowship
- Boehringer Ingelheim Fonds
- Human Frontier Science Program Fellowship [LT00079/2012]
- European Molecular Biology Organization Fellowship [ALTF 251-2011]
- Fulbright Award
- United Nations Educational, Scientific, and Cultural Organization L'Oreal National and International Women in Science Award
- Weizmann Institute of Science National Postdoctoral Award Program for Advancing Women in Science
- National Science Foundation
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Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning microbes in humans remain undefined. Here, we identified human symbiont bacterial species, in particular Bifidobacterium adolescentis, that could, alone, induce Th17 cells in the murine intestine. Similar to SFB, B. adolescentis was closely associated with the gut epithelium and engendered cognate Th17 cells without attendant inflammation. However, B. adolescentis elicited a transcriptional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th17 cell accumulation. Inoculation of mice with B. adolescentis exacerbated autoimmune arthritis in the K/BxN mouse model. Several off-theshelf probiotic preparations that include Bifidobacterium strains also drove intestinal Th17 cell accumulation.
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