Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 40, Pages 11318-11323Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1613337113
Keywords
dopamine; striosome; striatum; expansion microscopy
Categories
Funding
- William N. and Bernice E. Bumpus Foundation Grant Rapid Response Discovery Award Pilot [2013.1]
- Saks Kavanaugh Foundation
- CHDI Foundation [A-5552]
- Collaborative Center for X- linked Dystonia Parkinsonism at Massachusetts General Hospital
- McGovern Institute for Brain Research
- MIT Media Laboratory
- Open Philanthropy Project
- New York StemCell Foundation-Robertson Investigator Award
- Hertz fellowship
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The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed striosome-dendron bouquets, likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containing dendrites and also with afferents labeled by glutamatergic, GABAergic, and cholinergic markers and markers for astrocytic cells and fibers and connexin 43 puncta. We suggest that the striosome-dendron bouquets form specialized integrative units within the dopamine-containing nigral system. Given evidence that striosomes receive input from cortical regions related to the control of mood and motivation and that they link functionally to reinforcement and decision-making, the striosome-dendron bouquets could be critical to dopamine-related function in health and disease.
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