4.8 Article

Disparities in influenza mortality and transmission related to sociodemographic factors within Chicago in the pandemic of 1918

Publisher

NATL ACAD SCIENCES
DOI: 10.1073/pnas.1612838113

Keywords

influenza; 1918; transmission; mortality; sociodemographic

Funding

  1. US National Institutes of Health National Institute of General Medical Sciences MIDAS program [U54GM088491]
  2. Bill and Melinda Gates Foundation Vaccine Modeling Initiative
  3. US National Institutes of Health National Institute of Allergy and Infectious Disease [R01 AI102939]

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Social factors have been shown to create differential burden of influenza across different geographic areas. We explored the relationship between potential aggregate-level social determinants and mortality during the 1918 influenza pandemic in Chicago using a historical dataset of 7,971 influenza and pneumonia deaths. Census tract-level social factors, including rates of illiteracy, homeownership, population, and unemployment, were assessed as predictors of pandemic mortality in Chicago. Poisson models fit with generalized estimating equations (GEEs) were used to estimate the association between social factors and the risk of influenza and pneumonia mortality. The Poisson model showed that influenza and pneumoniamortality increased, on average, by 32.2% for every 10% increase in illiteracy rate adjusted for population density, homeownership, unemployment, and age. We also found a significant association between transmissibility and population density, illiteracy, and unemployment but not homeownership. Lastly, analysis of the point locations of reported influenza and pneumonia deaths revealed fine-scale spatiotemporal clustering. This study shows that living in census tracts with higher illiteracy rates increased the risk of influenza and pneumonia mortality during the 1918 influenza pandemic in Chicago. Our observation that disparities in structural determinants of neigh-borhood-level health lead to disparities in influenza incidence in this pandemic suggests that disparities and their determinants should remain targets of research and control in future pandemics.

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