Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 42, Pages 11973-11978Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1516110113
Keywords
organ patterning; leaf morphogenesis; class II HD-ZIP; class III HD-ZIP; MIR165/166
Categories
Funding
- European Research Council [GA 261081, GA 336295]
- Australian Research Council
- Deutsche Forschungsgemeinschaft [WE4281/7-1]
- Copenhagen Plant Science Centre
- Max Planck Society
- Villum Fonden [00007523] Funding Source: researchfish
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A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR) 165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.
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