Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 40, Pages 11208-11213Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1610347113
Keywords
cancer; intravasation; collagen; oriented invasion; microenvironment
Categories
Funding
- State Key Development Program for Basic Research of China [2013CB837200]
- National Natural Science Foundation of China [11474345, 11274200]
- Beijing Natural Science Foundation [7154221]
- National Cancer Institute [U54CA143803]
- Arizona State University startup funds
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In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (similar to 10 mg/mL protein concentration).
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