Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 39, Pages 10974-10979Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1613026113
Keywords
heterotrimeric G(o) protein; olfactory mucosa; olfactory bulb interneuron; tyrosine monooxygenase; sexual behavior
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Funding
- Bio & Medical Technology Development Program of the Korean National Research Foundation [NRF-2013M3C7A1056565, NRF-2015M3A9B4067067]
- NIH [Z01-ES101643]
- National Research Foundation of Korea [2015M3A9B4067067, 2013M3C7A1056565] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein G(o) is widely expressed in the MOE and VNO of mice. Early studies indicated that G(o) expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of G(o) in the MOE have remained poorly defined. Here, we examined the role of G(o) in the MOE using mice lacking the a subunit of G(o). Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that G(o) signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.
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