Journal
PRESSE MEDICALE
Volume 45, Issue 7-8, Pages 631-637Publisher
MASSON EDITEUR
DOI: 10.1016/j.lpm.2016.04.016
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Preeclampsia is a hypertensive disease of pregnancy due to abnormal utero-placental circulation. Hypoperfusion of the placenta and hypoxia/reoxygenation of the intervillous space are responsible of placental dysfunction. Trophoblastic factors are released in the maternal circulation and are responsible of the maternal endothelial dysfunction that characterize preeclampsia. Among those factors, the PlGF/sFlt-1 couple plays a major pathophysiologic role.
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