Journal
CHINESE CHEMICAL LETTERS
Volume 26, Issue 8, Pages 951-954Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.03.027
Keywords
Phenothiazines; Anti-tuberculosis; Chlorpromazine; TMC207
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Funding
- National High-Tech Research and Development Program (863Program) of China [2012AA020302]
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Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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