Journal
CHINESE CHEMICAL LETTERS
Volume 26, Issue 5, Pages 517-521Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.11.035
Keywords
Lonicera japonica; Homosecoiridoids; Loniaceticiridoside; Lonimalondialiridoside; Anti-inflammatory activity
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Funding
- National Natural Science Foundation of China (NNSFC) [20772156, 30825044]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT1007]
- National Science and Technology Project of China [2012ZX09301002-002, 2011ZX0 9307-002-01]
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Two new homosecoiridoids, named loniaceticiridoside (1) and lonimalondialiridoside (2), were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their structures including the absolute configuration were determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis. A proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1 and 2 are also discussed. (C) 2014 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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