Journal
CHINESE CHEMICAL LETTERS
Volume 26, Issue 12, Pages 1435-1438Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.10.019
Keywords
Gel electrophoresis; Nanoseparation; Colloidal material; DNA nanotechnology
Categories
Funding
- NNSFC [21273214, 21425521, 21521001]
- Hefei Center for Physical Science and Technology [2014FXCX010]
- [Collaborative Innovation Center of Suzhou Nano Science and Technology]
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The past years have witnessed a rapid development of DNA nanotechnology in nanomaterials science with a central focus on programmable material construction on the nanoscale. An efficient method is therefore highly desirable (but challenging) for analytical/preparative purification of DNA-conjugated nano-objects and their DNA-assemblies. In this regard, agarose gel electrophoresis, a traditional technique that has been invented for biomacromolecule separation, has found many innovative uses. This includes shape, size, charge, and ligand-valence separations of nanoparticle building blocks as well as monitoring a self-assembly process towards product identification and purification. 2015 Chinese Chemical Society and Institute of Material Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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