4.7 Article

Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones

Journal

CHINESE CHEMICAL LETTERS
Volume 26, Issue 10, Pages 1231-1235

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.07.022

Keywords

Copper; Arylation; Ketones; Naphthol

Funding

  1. National Natural Science Foundation of China [21102080, 21372138]
  2. Tsinghua University Initiative Scientific Research Program [2011Z02150]

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The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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