Journal
CHINESE CHEMICAL LETTERS
Volume 26, Issue 1, Pages 36-38Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.10.026
Keywords
On-line pretreatment; Liquid chromatography-mass spectrometry; Chloramphenicol; Honey
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Funding
- National Natural Science Foundation of China [21227006]
- Research Fund for the Doctoral Program of Higher Education [20110002110052]
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Chloramphenicol is an antibiotic and one of the potential contaminants in honey. Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey. In this work, an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive, reliable and higher throughput analysis was developed. With the methylcellulose-immobilized reversed-phase column, sugars in a honey sample were efficiently removed in 1 min. As a result, the limit of quantitation of chloramphenicol was 20 pg/mL (0.2 mu g/kg honey). (C) 2014 Jin-Ming Lin. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.
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