Journal
POLYMER SCIENCE SERIES B
Volume 58, Issue 6, Pages 720-729Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1560090416060191
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Funding
- Hong Kong, Macao and Taiwan Science and Technology Cooperation Program of China [2015DFH30180]
- Key Technology Research Project of Wuhan Municipality [2014060202010120]
- National Natural Science Foundation of China [51403168]
- Science and Technology Support of Hubei Province-Performance Evaluation of Public Technology Innovation Platform [2015BCE022]
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The objective of this study is to investigate the properties of poly(lactide-co-glycolide) with different composition ratios and PLGA-PEG-PLGA copolymers synthesized by ring-opening polymerization method. Their compositions, crystallization properties, thermal and degradation behaviors, hydrophilicity and biocompatibility were studied. Our results demonstrate that poly(lactide-co-glycolide) with a 90% lactide and PLGA-PEG-PLGA show some crystallization properties. While as the decrease of lactide content in polymers, poly(lactide-co-glycolide) become amorphous, whereas, their hydrophilicity have been improved on the contrary. Compared to poly(lactide-co-glycolide), the PLGA-PEG-PLGA copolymer has a better hydrophilicity for the existence of polyethylene glycol block. Furthermore, both these polymers display easy controlled degradation properties and good cell compatibility.
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