Polyacrylamide backbones for polyvalent bioconjugates using post-click chemistry

This paper reports the synthesis and application of acrylamide-type neoglycoconjugates interacting with practical targets. Polymer backbones with acrylamide and acrylamide derivatives bearing alkyne groups were prepared using living radical polymerization. Oligosaccharides were introduced into the backbones using copper-catalysed azide-alkyne cycloaddition post-click chemistry.