4.7 Article

Phosgene-free synthesis of non-ionic hydrophilic polyserine

Journal

POLYMER CHEMISTRY
Volume 7, Issue 3, Pages 519-522

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py01681a

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Funding

  1. National Natural Science Foundation of China [21174122, 21528402]
  2. Key Science Technology Innovation Team of Zhejiang Province [2013TD02]

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Non-ionic water-soluble poly-DL-serine (PSer) was synthesized from an activated urethane-type derivative of serine. SEC, NMR and MALDI-ToF analyses of the polypeptides revealed a controllable polymerization initiated by primary or secondary amines. PSer exhibited excellent solubility in water when the ratios of L-serine/D-serine units ranged from 5/5 to 8/2.

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