Journal
POLYMER CHEMISTRY
Volume 7, Issue 19, Pages 3221-3224Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py00250a
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Funding
- Science Foundation Ireland (SFI) [07/IN1/B1792, 13/IA/1840]
- European Union's Seventh Framework Programme [310250]
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Lysine-glyco-copolypeptide grafted superparamagnetic iron oxide nanoparticles were prepared through N-carboxyanhydride (NCA) copolymerization. Statistical and block copolymer arrangements were obtained while keeping the overall composition constant. Both type of nanoparticles are fully water dispersible, which is key for T-1-weighted magnetic resonance imaging (MRI) applications. A synergistic effect between siRNA loading and imaging properties was observed in the statistical copolymer arrangement allowed a significantly higher loading while retaining full particle dispersion, as required for T-1-weighting.
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