Journal
POLYMER
Volume 101, Issue -, Pages 139-150Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2016.08.059
Keywords
Organosilane; Segregation; Thermo-responsive thin films
Categories
Funding
- National Institute of General Medical Sciences of the National Institutes of Health [1R15GM097626-01A1]
- Ministry of Education in Saudi Arabia
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In a previous study, we demonstrated the feasibility of retaining poly(N-isopropylacrylamide) (pNIPAAm) on hydroxylated surfaces by spin-coating a blend of pNIPAAm with a small amount of 3-aminopropyltriethoxysilane (APTES), an organosilane, followed by thermal annealing. In this study, we detail the conditions for retaining pNIPAAm films by APTES. Our results show that the difference in surface energy between pNIPAAm and APTES in the blended film resulted in the segregation of APTES molecules to the film/substrate interface, as verified by XPS, during annealing, and the segregated APTES molecules cross-linked to form the APTES network, thus entrapping pNIPAAm. The retained pNIPAAm films (20-40 nm) exhibited thermo-responsive behavior, determined by water contact angles and film thickness in water at temperatures above and below the lower critical solution temperature of pNIPAAm, as well as good cell attachment and rapid detachment (<10 min). The gained insights would allow a better design of these thermo-responsive surfaces for cell sheet engineering and other relevant applications. (C) 2016 Elsevier Ltd. All rights reserved.
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