Journal
CHILDS NERVOUS SYSTEM
Volume 31, Issue 8, Pages 1239-1245Publisher
SPRINGER
DOI: 10.1007/s00381-015-2767-6
Keywords
Diffusion tensor imaging; Fractional anisotropy; Mean diffusivity; Pediatric; Spinal cord
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Funding
- National Center for Research Resources
- National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health [UL1T000424]
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Obtaining fast, reliable, high-resolution diffusion tensor imaging (DTI) of the pediatric cervical spinal cord (CSC) is challenging, given the multitude of technical limitations involved. Overcoming these limitations may further potentiate DTI as a valuable quantitative tool in evaluating the pediatric CSC. Sixteen patients (9 girls and 7 boys) with hypoxic brain injury, craniocervical junction malformations, and head trauma were included in this retrospective study. Region of interests were placed from C1-C2 through C7-T1 consecutively at the cervical intervertebral disc levels. DTI metrics were compared with a pediatric DTI database of healthy controls. Clinical background and outcomes were tabulated. Patients with hypoxic brain injury, Chiari I and II malformations, and head trauma demonstrated lower fractional anisotropy values than that of healthy controls at certain cervical intervertebral disc levels. DTI may be a promising modality for providing additional information beyond that of conventional magnetic resonance imaging in pediatric central nervous system disorders.
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