Journal
PLANTA MEDICA
Volume 82, Issue 9-10, Pages 775-789Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0042-101353
Keywords
marine-sourced drugs; clinical trials; cancer; HIV
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The potential of the marine environment to produce candidate compounds (structures) as leads to, or even direct drugs from, has been actively discussed for the last 50 or so years. Over this time frame, several compounds have led to drugs, usually in the area of cancer (due to funding sources). This review is designed to show where there have been successes, but also to show that in a number of disease areas, there are structures originally isolated from marine invertebrates and free-living microbes that have potential, but will need to be adopted by pharmaceutical houses in order to maximize their potential.
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