Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 71, Issue 1, Pages 88-89Publisher
SPRINGER
DOI: 10.1007/s11130-016-0530-0
Keywords
Dietary polyphenols; alpha-glucosidase; alpha-amylase; Dipeptidyl peptidase 4; Diabetes
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In this work we have focused on the inhibition of three different enzymes with a role in postprandial glucose management: alpha-amylase, alpha-glucosidase and dipeptidyl peptidase 4. The assortment of 29 monomeric phenolic compounds was first screened at a single concentration. Next, the IC50 values of tested compounds were evaluated for compounds that considerably inhibited any of the enzymes. Nordihydroguaiaretic acid, a phenolic compound abundant in Creosote bush Larrea tridentata, possessed inhibitory activity for all tested enzymes. This in vitro mechanism of action supports traditional use of Creosote bush in diabetes treatment.
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