Journal
PHYTOCHEMISTRY LETTERS
Volume 16, Issue -, Pages 156-162Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2016.03.015
Keywords
Pteris semipinnata; Ent-kauranoic acid; Pterisolic acid G; Pterisolic acid H; Diterpenoids; Cytotoxicity
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Funding
- program for Outstanding Young Teachers in Higher Education Institutions of Guangdong Province [Yq2013045]
- Special Funds from Central Finance of China in Support of the Development of Local Colleges and Universities [Educational finance] [276 (2014)]
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Two new hydroxylated ent-kauranoic acids, pterisolic acid G (1) and pterisolic acid H (3), together with five known ent-kaurane-type diterpenoids (2 and 4-7) were isolated from the whole plant of Pteris semipinnata L. The structures of compounds 1-3 were elucidated on the basis of HR-MS, 1D and 2D NMR analysis, and the absolute configuration of compounds 1 and 2 were determined by the results of single crystal X-ray diffraction experiment. Compounds 1-4 and 6-7 were evaluated in vitro cytotoxicity against the A549, CT26.WT, and Hep G2 cells, and compounds 4 and 6 possessed varying degrees of activity. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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