Journal
PHYTOCHEMISTRY LETTERS
Volume 16, Issue -, Pages 87-91Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2016.03.007
Keywords
Ganoderma lucidum; Lanostane; Triterpenoids
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Funding
- National Natural Science Foundation of China [81274047, 81473334, 81303146, 81503201]
- Education Department of Liaoning Province [LR2014025, L2014352]
- Outstanding Youth Science and Technology Talents of Dalian [2014J11JH132]
- Innovation Team of Dalian Medical University
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Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1-4). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimulated macrophages showed that the isolated triterpenoids had no inhibitory effects on p-glycoprotein (p-gp). (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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