Journal
PHYTOCHEMISTRY
Volume 121, Issue -, Pages 58-64Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.10.002
Keywords
Lespedeza cuneata; Leguminosae; Phenylpropanoid glucosides; Lignan glycosides; Inflammatory bowel disease; Xbp1 promoter
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Funding
- National Megaproject for Innovative Drugs [2012ZX09301002-002]
- National Natural Science Foundation of China [81560632, 81202546]
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Four phenylpropanoid glucosides (1-4) and five lignan glycosides (5-9) were isolated from the aerial parts of Lespedeza cuneata, together with three known lignan glycosides (10-12). Their structures were elucidated on the basis of spectroscopic analyses, and the absolute configurations of compounds 5-9 were determined from the CD spectra. In addition, the compounds were tested for their ability to activate the transcription effect on xbp1 promoter. Compounds 4, 5, 7, 9, 10, and 12 could activate the transcription of xbp1 to varying degrees, with EC50 values ranging from 0.18 to 0.64 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
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