Journal
PHYTOCHEMISTRY
Volume 132, Issue -, Pages 95-101Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2016.10.001
Keywords
Favolaschia calocera; Mycenaceae; Structure elucidation; Strobilurins; Calocerin; Antifungal activity; Cytotoxicity
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Funding
- ASAFEM Project [IC-070]
- German Academic Exchange Service
- Kenya National Council for Science and Technology (NACOSTI)
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Eight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-l-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity. (C) 2016 Elsevier Ltd. All rights reserved.
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