Journal
PHYTOCHEMISTRY
Volume 131, Issue -, Pages 124-129Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2016.08.009
Keywords
Grangea maderaspatana; Asteraceae; Diterpenes; Anti-inflammatory
Categories
Funding
- Ministry of Science and Technology of Taiwan [MOST 105-2911-I-002-302, 103-2911-I-002-303, 103-2325-B-039-008, 103-2325-B-039-007-CC1, 102-2320-B-037-012-MY2, NSC 102-2628-B-037-003-MY3, MOST 103-2320-B-037-005-MY2, MOST 103-2628-B-037-001-MY3]
- National Health Research Institutes [NHRI-EX103-10241BI]
- Ministry of Education
- Ministry of Education (Chinese medicine research center, China Medical University)
- Kaohsiung Medical University [KMU-TP103H02]
- Ministry of Health and Welfare of Taiwan [MOHW105-TDU-B-212-134007]
- health and welfare surcharge of tobacco products
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Phytochemical investigation of the ethanolic extract of Grangea maderaspatana led to isolation of gramaderins A-D, together with thirteen known compounds. All isolates were assayed for their anti-inflammatory activities. Consequently, 5,7-dihydroxy-3,6,3',4',5'-pentamethoxyflavone and 5,3'-dihydroxy-3,6,7,4',5'-pentamethoxyflavone showed significant bioactivities by inhibiting superoxide anion generation. 8-Acetoxy-pentadeca-1,9Z,14-trien-4.6-diyne-3-ol also demonstrated potent inhibition on elastase release. The gramaderins A/C (beta-alkyl linked gamma-lactone) and gramaderins B/D (alpha-alkyl linked gamma-lactone) co-exist in this plant material, of which the latter derivatives are few in nature. Gramaderins C/D possess a special linear dilactone diterpene skeleton, which never been reported. (C) 2016 Elsevier Ltd. All rights reserved.
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