Journal
PHYTOCHEMISTRY
Volume 122, Issue -, Pages 146-153Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.12.005
Keywords
Vitellaria paradoxa (Sapotaceae); Shea meal; Thiolysis; Proanthocyanidins; Galloylated; Ascaris suum; Anthelmintic; LC-MS
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Funding
- European Commission (Marie Curie Initial Training Network) [PITN-GA-2011-289377]
- Danish Council for Independent Research (Technology and Production Sciences) [12-126630]
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Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography-mass spectrometry. These PA were galloylated (approximate to 40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384 Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575 mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.
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