Journal
PHYTOCHEMISTRY
Volume 122, Issue -, Pages 238-245Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.11.013
Keywords
Eupatorium chinense; Compositae; Chinese folk medicine; Benzofuran; Antiviral activity
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Funding
- National Natural Science Foundation of China [81172947, 81202428]
- Program for New Century Excellent Talents in University [NCET-12-0676]
- Ministry of Science and Technology of China [2013DFM30080, 2012ZX09103201-056, 2013BAI11B05]
- Science and Technology Development Fund of Macau [042-2014-A1]
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Eleven benzofuran dimers, (+)-dieupachinins A-E, (-)-dieupachinins A-E and dieupachinin F, a benzofuran trimer trieupachinin A, as well as seven known compounds were isolated from the roots of Eupatorium chinense. The enantiomers of racemates dieupachinins A-E were separated by chiral HPLC. The structures with absolute configurations were elucidated on the basis of spectroscopic data, X-ray diffraction analysis, and circular dichroism experiments. The isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus (RSV). (C) 2015 Elsevier Ltd. All rights reserved.
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