Journal
PHYTOCHEMISTRY
Volume 122, Issue -, Pages 119-125Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.11.014
Keywords
Rabdosia serra; Lamiaceae; ent-Kaurane diterpenoids; Cytotoxic activity
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Funding
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09301-001]
- National Natural Sciences Foundation of China [30901851]
- State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences [SIMM0907 KF-04]
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Investigation of the hydrophobic extract of Rabdosia serra (Lamiaceae) led to the isolation of seven ent-6,7-secokaurane diterpenoids rabdosins E-K, along with twelve known ent-kaurane diterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of rabdosins E, F, H and I were determined by single -crystal X-ray diffraction, with rabdosin E having a 3,20 -epoxy group. These diterpenoids could be divided into two types according to their skeletons: rabdoMns E -J are ent-6,20-epoxy-6,7-secokaur-1,7-olides, and rabdosin K is an ent-6,7-secokaur-7,20-olide. Cytotoxicity evaluation showed that serrin B, serrin A, isodocarpin and lushanrubescensin J exhibited weak to moderate cytotoxic activities (IC50 < 10 mu M) against two human cancer cell lines. (C) 2015 Elsevier Ltd. All rights reserved.
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