Journal
PHYSIOLOGY & BEHAVIOR
Volume 164, Issue -, Pages 482-485Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2016.04.026
Keywords
Low calorie sweetener; Gut hormones; Gastric emptying
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Funding
- Biotechnology and Biological Sciences Research Council [BB/G005591/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/G005591/1] Funding Source: researchfish
- BBSRC [BB/G005591/1] Funding Source: UKRI
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The importance of nutrient induced gut-brain signalling in the regulation of human food intake has become an increasing focus of research. Much of the caloric excess consumed comes from dietary sugars, but our knowledge about the mechanisms mediating the physiological and appetitive effects of sweet tastants in the human gut and gut-brain axis is far from complete. The comparative effects of natural sugars vs low calorie sweeteners are also poorly understood. Research in animal and cellular models has suggested a key functional role in gut endocrine cells for the sweet taste receptors previously well described in oral taste. However human studies to date have very consistently failed to show that activation of the sweet taste receptor by low calorie sweeteners placed in the human gut fails to replicate any of the effects on gastric motility, gut hormones or appetitive responses evoked by caloric sugars. (C) 2016 Published by Elsevier Inc.
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