Journal
PHYSIOLOGICAL REVIEWS
Volume 96, Issue 3, Pages 1093-1126Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00036.2015
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Funding
- American Heart Association
- Burroughs Wellcome Foundation
- National Institutes of Health (NIH) [R01 HL123968, R01 HL126527, R01 HL128170, R01 HL130020]
- NIH Progenitor Cell Biology Jump Start Award
- Stanford Cardiovascular Institute Seed Grant
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Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug treatment. In this review, we describe how hiPSCs could transition cardiac healthcare away from simple disease diagnosis to prediction and prevention, bridging the gap between basic and clinical research to bring the best science to every patient.
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