Journal
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
Volume 27, Issue 4, Pages 909-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pmr.2016.06.008
Keywords
alpha(2)-macroglobulin (A2M); Inflammation; Anti-inflammatory; Cytokines; Arthritis; Osteoarthritis; Discogenic back pain; Autologous
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alpha(2)-Macroglobulin (A2M) is a plasma glycoprotein best known for its ability to inhibit a broad spectrum of serine, threonine, and metalloproteases as well as inflammatory cytokines by a unique bait-and-trap method. A2M has emerged as a unique potential treatment of cartilage-based pathology and inflammatory arthritides. This article describes the unique method by which A2M not only inhibits the associated inflammatory cascade but also disrupts the catabolic process of cartilage degeneration. Autologous concentrated A2M from plasma is currently in use to successfully treat various painful arthritides. Future directions will focus on recombinant variants that enhance its antiinflammatory and disease-modifying potential.
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