Journal
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
Volume 27, Issue 2, Pages 503-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pmr.2015.12.007
Keywords
Neuropathology; Trauma; Traumatic brain injury; Chronic traumatic encephalopathy; Tau; Concussion; Subconcussion
Categories
Funding
- NIA NIH HHS [P30 AG013846, T32 AG036697] Funding Source: Medline
- NINDS NIH HHS [U01 NS086659, F32 NS096803] Funding Source: Medline
- RRD VA [I01 RX000991] Funding Source: Medline
- Intramural VA [VA999999] Funding Source: Medline
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Repeated concussive and subconcussive trauma is associated with the later development of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with clinical symptoms in multiple domains and a unique pattern of pathologic changes. CTE has been linked to boxing and American football; CTE has also been identified in soccer, ice hockey, baseball, rugby, and military service. To date, most large studies of CTE have come from enriched cohorts associated with brain bank donations for traumatic brain injury, although several recent studies re-examining neurodegenerative disease brain banks suggest that CTE is more common than is currently appreciated.
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