Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 18, Issue 46, Pages 31664-31669Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cp06305e
Keywords
-
Funding
- Canon Foundation in Europe
- JSPS KAKENHI [26707020, 25103012, 26115709]
- [25-1270]
- [27-2049]
Ask authors/readers for more resources
In this study, nanoscale hydration dynamics of DNA-lipid blend dry films are investigated via small angle X-ray diffraction. Compared to the hydration of lipid films, fragmented short DNA strands and counterions in stacked lipid layers dramatically accelerate both the relaxation of the lamellar distance to a metastable interval and the subsequent peeling-off process of lipid bilayers. Moreover, genome-sized long DNA and counterions accelerate the relaxation process, but suppress the peeling-off process and simultaneously induce a damped-oscillation of the lamellar interval; this is probably due to the viscoelastic properties of the entangled long DNA dissolved in hydrated water between the stacked lipid bilayers. This study's findings can pave the way for producing cell-sized liposomes, which efficiently encapsulate any arbitrary sized DNA through natural swelling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available