Journal
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Volume 32, Issue 1, Pages 12-22Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2015.12.007
Keywords
PET; Time-of-flight PET; Image quality; Scintillators; Photo-sensors; Image reconstruction
Funding
- National Institutes of Health [R01-CA113941, R01-EB009056]
- NATIONAL CANCER INSTITUTE [R01CA113941] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB009056] Funding Source: NIH RePORTER
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This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs. (C) 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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