Journal
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
Volume 32, Issue 4, Pages 214-223Publisher
WILEY
DOI: 10.1111/phpp.12249
Keywords
cytokine; filaggrin; narrowband ultraviolet B; urocanic acid; vitamin D
Categories
Funding
- Horizon 2020 ISCH COST Action StanDerm [TD1206]
- Lundbeck Foundation [R139-2012-12679] Funding Source: researchfish
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Background/PurposeUrocanic acid (UCA) absorbs ultraviolet (UV)B radiation in the epidermis which may interfere with phototherapy. Therefore, the influence of individual levels of UCA on immune reactivity and vitamin D synthesis induced by narrowband UVB radiation was assessed. MethodsTwenty-eight subjects with irritant contact dermatitis of the hands were irradiated with suberythemal doses of narrowband UVB radiation on their unaffected lower forearms on three consecutive days. Stratum corneum tape strips and epidermal interstitial fluid (ISF) as well as blood samples were analyzed. ResultsNarrowband UVB irradiation led to the conversion of trans-UCA into its cis-isomer in the epidermis. The observed increase in 25-hydroxyvitamin D serum concentrations was inversely correlated with the baseline levels of trans-UCA. Furthermore, UVB irradiation induced significant changes in the levels of CXCL10/IP-10, CCL2/MCP-1, CCL4/MIP-1, and the IL-1RA/IL-1 ratio. The levels of IL-1 and CXCL9/MIG showed a trend toward increase. The changes in the levels of inflammatory and immunomodulatory mediators did not depend on baseline levels of trans-UCA. ConclusionThe results suggest that epidermal levels of trans-UCA affect vitamin D synthesis, but not cutaneous immune reactivity upon repeated exposure to suberythemal doses of narrowband UVB radiation. However, this requires further exploration.
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