Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 15, Issue 4, Pages 466-480Publisher
SPRINGERNATURE
DOI: 10.1039/c5pp00456j
Keywords
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Funding
- National Program on Key Basic Research Project [2013CB734000]
- National Natural Science Foundation of China [81370085]
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001]
- Fundamental Research Funds of Shandong University [2014JC008]
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Bioluminescence-based techniques, such as bioluminescence imaging, BRET and dual-luciferase reporter assay systems, have been widely used to examine a myriad of biological processes. Coelenterazine (CTZ), a luciferin or light-producing compound found in bioluminescent organisms, has sparked great curiosity and interest in searching for analogues with improved photochemical properties. This review summarizes the current development of coelenterazine analogues, their bioluminescence properties, and the rational design of caged coelenterazine towards biotargets, as well as their applications in bioassays. It should be emphasized that the design of caged luciferins can provide valuable insight into detailed molecular processes in organisms and will be a trend in the development of bioluminescent molecules.
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