Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 191, Issue 7, Pages 971-974Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2015.1135151
Keywords
-Aminoalcohol; oxazoline; sulfur; solvent-free condition; Willgerodt-Kindler reaction
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We report an efficient and green protocol for the synthesis of 2-oxazolines by the reaction of aromatic nitriles with -aminoalcohols using sulfur under solvent-free conditions. The reaction occurs via the Willgerodt-Kindler mechanism followed by transamidation and dehydrosulfuration. This methodology offers several advantages such as good yields, mild and practical reaction conditions, simple work-up procedure, and broad substrate scope, which makes the process simple, convenient, and environmental-friendly. [GRAPHICS]
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