Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 371, Issue 1708, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2016.0011
Keywords
interoception; visceromotor; major depressive disorder; fMRI; prediction
Categories
Funding
- National Institutes on Aging [R01 AG030311]
- National Cancer Institute [U01 CA193632]
- National Science Foundation [1638234]
- US Army Research Institute for the Behavioral and Social Sciences [W911NF-15-1-0647, W911NF-16-1-0191]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1638234] Funding Source: National Science Foundation
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In this paper, we integrate recent theoretical and empirical developments in predictive coding and active inference accounts of interoception (including the Embodied Predictive Interoception Coding model) with working hypotheses from the theory of constructed emotion to propose a biologically plausible unified theory of the mind that places metabolism and energy regulation (i.e. allostasis), as well as the sensory consequences of that regulation (i.e. interoception), at its core. We then consider the implications of this approach for understanding depression. We speculate that depression is a disorder of allostasis, whose myriad symptoms result from a 'locked in' brain that is relatively insensitive to its sensory context. We conclude with a brief discussion of the ways our approach might reveal new insights for the treatment of depression. This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.
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