Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 372, Issue 1713, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2015.0480
Keywords
tandem duplication; genome duplication; homeobox; Lepidoptera; Mollusca; Mammalia
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Funding
- European Research Council under the European Union (ERC grant) [268513]
- European Research Council (ERC) [268513] Funding Source: European Research Council (ERC)
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Gene duplications and gene losses have been frequent events in the evolution of animal genomes, with the balance between these two dynamic processes contributing to major differences in gene number between species. After gene duplication, it is common for both daughter genes to accumulate sequence change at approximately equal rates. In some cases, however, the accumulation of sequence change is highly uneven with one copy radically diverging from its paralogue. Such 'asymmetric evolution' seems commoner after tandem gene duplication than after whole-genome duplication, and can generate substantially novel genes. We describe examples of asymmetric evolution in duplicated homeobox genes of moths, molluscs and mammals, in each case generating new homeobox genes that were recruited to novel developmental roles. The prevalence of asymmetric divergence of gene duplicates has been underappreciated, in part, because the origin of highly divergent genes can be difficult to resolve using standard phylogenetic methods. This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'.
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