Journal
PHARMACOLOGY & THERAPEUTICS
Volume 168, Issue -, Pages 98-112Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2016.09.011
Keywords
Inflammation; Tumor; Cancer; Chemokines; Cytokines; Exosomes
Categories
Funding
- Russian Science Foundation [14-25-00160]
- Russian Science Foundation [14-25-00160] Funding Source: Russian Science Foundation
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Relationship between inflammation and cancer is now well-established and represents a paradigm that our immune response does not necessarily serves solely to protect us from infections and cancer. Many specific mechanisms that link chronic inflammation to cancer promotion and metastasis have been uncovered in the recent years. Here we are focusing on the effects that tumors may exert on inflammatory cascades, tuning the immune system ability to cause tumor promotion or regression. In particular, we discuss the contributions of chemokines, cytokines and exosomes to the processes such as induction of inflammation and tumorigenesis. Overall, tumor-elicited inflammation is a key driver of tumor progression and an essential component of tumor microenvironment. (C) 2016 Elsevier Inc. All rights reserved.
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