Journal
PHARMACOLOGICAL RESEARCH
Volume 114, Issue -, Pages 56-66Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.10.016
Keywords
Cancer gene therapy; Gene delivery; Nanoparticles
Categories
Funding
- NIH [R01CA161953, R01CA172455]
- College of Engineering Dean's Fellowship at University of Washington
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Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment. (C) 2016 Published by Elsevier Ltd.
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