Journal
PHARMACOLOGICAL RESEARCH
Volume 109, Issue -, Pages 119-131Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.02.020
Keywords
Acetaminophen; Hepatic toxicity; trpv1; Necroptosis; Caspase; DAMPs
Categories
Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2012-1753, PICT 2014-0476]
- National Institutes of Health [DK069557]
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Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to be safe when administered within its therapeutic range, but in cases of acute intoxication, hepatotoxicity can occur. APAP overdose is the leading cause of acute liver failure in the northern hemisphere. Historically, studies on APAP toxicity have been focused on liver, with alterations in brain function attributed to secondary effects of acute liver failure. However, in the last decade the pharmacological mechanism of APAP as a cannabinoid system modulator has been documented and some articles have reported in situ toxicity by APAP in brain tissue at high doses. Paradoxically, low doses of APAP have been reported to produce the opposite, neuroprotective effects. In this paper we present a comprehensive, up-to-date overview of hepatic toxicity as well as a thorough review of both toxic and beneficial effects of APAP in brain. (C) 2016 Elsevier Ltd. All rights reserved.
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