Journal
PHARMACOLOGICAL RESEARCH
Volume 111, Issue -, Pages 774-783Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.07.035
Keywords
Histamine; Histamine receptors; Astrocyte function
Categories
Funding
- Slovenian Agency for Research (ARRS) [ARRS-P3-019, P3-067, ARRS-J3-0024, ARRS-J3-081, ARRS-J1-2014]
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Astrocytes support the brain through numerous functional interactions in health and disease. The recent advances in our knowledge of astrocyte involvement in various neurological disorders raised up several questions about their role and functioning in the central nervous system. From the evidence discussed in this review, we show that histamine importantly influences the main astrocytic activities such as ion homeostasis, energy metabolism, neurotransmitter clearance, neurotrophic activity and immune response. These processes are mediated through at least three histamine receptor subtypes, H-1, H-2 and H-3, expressed on the astrocyte surface. Thus, we recognize histamine as an important player in the modulation of astrocytic functions that deserves further considerations in exploring involvement of astrocytes in neurological disorders. (C) 2016 Elsevier Ltd. All rights reserved.
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