Journal
PHARMACOLOGICAL RESEARCH
Volume 108, Issue -, Pages 57-64Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.04.010
Keywords
Notch; Fibrosis; Myofibroblast
Categories
Funding
- National Institutes of Health, USA [HL052285, HL112880]
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The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states. Close interactions of Notch signaling pathway with other signaling pathways have been identified. In this review, current knowledge on the role of the Notch signaling with special focus on fibrosis and its potential as a therapeutic target is summarized. (C) 2016 Elsevier Ltd. All rights reserved.
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