Journal
CHEMOSPHERE
Volume 120, Issue -, Pages 92-99Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2014.06.011
Keywords
Nanoparticles; Metallothionein; Heat shock proteins; Superoxide dismutase; Reference genes; Crustacean
Categories
Funding
- US EPA [R833339]
- Guangxi Natural Science Foundation [2013GXNSFCA019009]
- China Postdoctoral Science Foundation [2012M521658]
- EPA [R833339, 909177] Funding Source: Federal RePORTER
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The ever-increasing production and use of nanocrystaline semiconductors (Quantum dots; QDs) will inevitably result in increased appearance of these nanomaterials in the aquatic environment. However, the behavior and potential toxicity of heavy metal constituted nanoparticulates in aquatic invertebrates is largely unknown, especially with regard to molecular responses. The freshwater crustacean Daphnia pulex is a well-suited toxicological and ecological model to study molecular responses to environmental stressors. In this study, D. pulex were exposed for 48 h to sublethal doses of QDs (25% and 50% of LC50) with differing spectral properties (CdTe and CdSe/ZnS QDs) and Cd and Zn salts. Our data suggest that acute exposure to both CdSO4 and Cd-based QDs leads to Cd uptake in vivo, which was biologically supported by the observation of increased expression of metallothionein (MT-1). Furthermore, Cd, Zn, and CdSe/ZnS QDs induced different patterns of gene expression regarding stress defense and DNA repair, which furthers our knowledge regarding which response pathways are affected by nanoparticulate forms of metals versus ionic forms in aquatic crustaceans. (C) 2014 Elsevier Ltd. All rights reserved.
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